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In the middle of the sixth century, the world's smallest organism collided with the world's mightiest empire. With the death of twenty-five million people, the Roman Empire, under her last great emperor, Justinian, was decimated. Before Yersinia pestis, the bacterium that carries bubonic plague, was finished, both the Roman and Persian empires were easy pickings for the armies of Muhammad on their conquering march out of Arabia. In its wake, the plague - history's first pandemic - marked the transition from the age of Mediterranean empires to the age of ...